With Monkeypox being declared a global health emergency, the world is on high alert. After three cases were reported in Pakistan, India has also increased its vigilance. Outbreaks of Monkeypox have been observed in several African countries. While there is extensive information available about Monkeypox, many people remain confused about the differences between Monkeypox and Chickenpox. Both diseases share similar symptoms, such as fever and rashes, but they are caused by different viruses. Monkeypox is caused by the Monkeypox virus, while Chickenpox is caused by the Varicella-Zoster virus. Monkeypox tends to be more severe, with symptoms lasting longer and a higher risk of complications. Understanding these differences is crucial for determining which illness poses a greater threat and how to respond effectively.